Alrighty then... Here's what I use, and if I ever have a virus it's gone within a couple seconds...
Maxthon (Formerly MyIE2, allows tab-browsing)
AVG (Free version works great, detects a virus on contact)
Windows Firewall [Control panel: Windows Firewall; On] (Simple, yet effective)
Service Pack 2 helps
Port Magic (AOL thing)
Router
This is mainly all I use, and I haven't had any problems with viruses. All these things (excluding the router) are simple, free, and effective. By the way; I'm using XP. I do have Norton, but subscription expired and I am going to, possibly and probably, get AVG pro.
Maxthon is basically IE (without major bugs and junk) + FireFox/Mozilla.
~Celestial